Estimating Cell Depth from Somatic Mutations
نویسندگان
چکیده
منابع مشابه
Estimating Cell Depth from Somatic Mutations
The depth of a cell of a multicellular organism is the number of cell divisions it underwent since the zygote, and knowing this basic cell property would help address fundamental problems in several areas of biology. At present, the depths of the vast majority of human and mouse cell types are unknown. Here, we show a method for estimating the depth of a cell by analyzing somatic mutations in i...
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A large body of data has now been accumulated concerning the ways in which heritable mutations can affect protein structure. Such mutations are usually presumed to arise in the germ line, and are studied by progeny analyses of various types. Today, I would like to consider how somatic mutations might be genetically predisposed and thereby made available to an organism during its adaptation to e...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2008
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1000058